US 6,271,665 B1Granted

Extra slice spin tagging (EST) magnetic resonance imaging for determining perfusion

OwnerStuart S. Berr, Vu Minh Maiinventors

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Abstract

A magnetic resonance technique to measure perfusion of fluid to tissue by inverting all the spins in fluid water hydrogen nuclei of the subject with a non-spatially-selective radiofrequency (RF) pulse and immediately reinverting the spins in an imaging plane of interest such that the spins in the imaging plane experience minimal perturbation of their magnetization while the spins outside the plane (extraslice) are inverted (tagged). To account for signal loss effects of magnetization transfer (MT), a control image is obtained by applying two non-selective inversion pulses and creating a perfusion-weighted image by subtracting the tagged image from the control image. When this tagged image is subtracted from a “control” image, the resulting intensity arises solely from the tagged spins that have flowed into the imaging plane. This resultant image is referred to as a perfusion weighted image, because its intensity is a function of the rate of perfusion into the imaging plane. The intensity is also a function of the relaxation rate of the inflowing spins, the partition coefficient of the spins, and the relaxation rate of the stationary tissue. Estimates on these values can be made and can be used to calculate a perfusion map, which is an image that is created in which the intensity of each voxel is proportional to the perfusion of spins into the voxel. EST MRI is entirely noninvasive and overcomes some of the problems associated with the other noninvasive MRI techniques.

Claims11

Dependent claims

A spin labeling magnetic resonance method for measuring perfusion of fluid into an area without the use of ionizing radiation or exogenous tracer and wherein the fluid outside the area is tagged prior to perfusion into said area, said method comprising the steps of:

(a) choosing an arbitrary area of interest to image;
(b) magnetically tagging nuclei in said fluid outside said imagining area using a nonselective radio frequency (RF) inversion pulse followed immediately by a selective RF pulse-magnetic field gradient combination coincident with the imaging plane which re-inverts spins in the imaging plane and leaves the spins outside the plane inverted (tagged);
(c) allowing time for the tagged nuclei to perfuse into said imaging area;
(d) collecting tag image information in a rapid manner and generating an image where the intensity is decreased by the tagged nuclei that have traveled into the imaging plane;
(e) collecting a control image in a manner exactly the same as that of the tagged images except that two non-selective RF pulses are used which leaves the spins outside the imaging plane untagged but imparts the same amount of signal loss due to magnetization transfer (MT);
(f) processing said images to create a perfusion weighted image by calculating on a pixel by pixel basis the difference between the tag and control image, for which the intensity is a function of the perfusion rates;
or
(g) processing said images to determine the quantity of said fluid per quantity of said mass of image volume per unit time which has perfused into said imaging area as a function of spatial location.

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