Process for producing amino acid amides
AssigneeNovartis AG
InventorsRatna Shekhar, Michael John Girgis
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for the synthesis of amino acid amides which comprise providing a fixed bed of a cation exchange resin, admixing a primary alcohol and an amino acid in a reaction vessel in fluid communication with the fixed bed to form a first mixture, contacting the fixed bed of cation exchange resin with the first mixture for a period of time, thereby causing amino acid ester intermediate to be formed on the cation exchange resin, adding liquid ammonia to the reaction vessel, and contacting the fixed bed of cation exchange resin with ammonia, the fixed bed having previously been contacted with the first mixture.
Claims16
A method for the synthesis of amino acid amides which comprises:
- providing a fixed bed of a cation exchange resin;
- admixing a primary alcohol and an amino acid in a reaction vessel in fluid communication with the fixed bed to form a first mixture;
- contacting the fixed bed of cation exchange resin with the first mixture for a period of time, thereby causing amino acid ester intermediate to be formed on the cation exchange resin;
- adding liquid ammonia to the reaction vessel to form a second mixture;
- and
- contacting the fixed bed of cation exchange resin with the second mixture, the fixed bed having previously been contacted with the first mixture.
Dependencies are inferred from the claim text.