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US 6,271,374 B1Granted
Stable crystalline (6S)- and (6R)-tetrahydrofolic acid
AssigneeEprova AG
InventorsHans Rudolf Müller, Martin Ulmann, Rudolf Moser, Thomas Ammann
Life of this patent
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Abstract
Pure and extremely stable crystalline (6S)- and (6R)-tetrahydrofolic acids, absolutely inert even when exposed to air and elevated temperature without stabilizers being added, are prepared by a crystallization process at a pH of ≧3.5 for the preparation of crystalline (6S)-tetrahydrofolic acid and at a pH of ≧2 for the preparation of crystalline (6R)-tetrahydrofolic acid.
Claims17
Crystalline (6S)-tetrahydrofolic acid having a purity by weight of more than 98%.
Dependencies are inferred from the claim text.