Recombinant mistletoe lectin (rML)

An isolated nucleic acid molecule comprising a nucleotide sequence coding for the A chain of the mistletoe lectin or a fragment thereof having the biological activity of enzymatic inactivation of ribosomes.

An isolated nucleic acid molecule comprising a nucleotide sequence coding for the B chain of the mistletoe lectin or a fragment thereof having the biological activity of carbohydrate binding.

An isolated nucleic acid molecule comprising the nucleotide sequence depicted in FIG. 4a (SEQ ID NO:

• 30) or comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence as set forth in FIG. 4a (SEQ ID NO:
• 31).

An isolated nucleic acid molecule comprising the nucleotide sequence depicted in FIG. 4b (SEQ ID NO:

• 32) or comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence as set forth in FIG. 4b (SEQ ID NO:
• 33).

An isolated nucleic acid molecule comprising a nucleotide sequence encoding mistletoe lectin having one or more of the following biological activities:

• cytotoxicity, immunostimulation, endorphin stimulation, stimulation of release of inflamatory cytokines, apoptosis induction or antigenicity.

An isolated nucleic acid molecule comprising the nucleotide sequence depicted in FIG. 4c (SEQ ID NO:

• 34).