Polynucleotide encoding secretory membrane protein
AssigneeChugai Research Institute for Molecular Medicine, Inc.
InventorsNaoki Kimura, Tomoko Toyoshima
Life of this patent
Estimating the term…
Abstract
Three genes encoding secretory membrane proteins have been successfully isolated from an osteoblast-like cell line by a method for specifically cloning secretory membrane proteins. One of these genes encodes a novel receptor protein. The protein has only the extracellular region, binds to the cell membrane via a GPI anchor, and carries therein a cysteine-rich, repetitive region commonly conserved in the TNF receptor super family. Overexpression of this protein in osteoblast-like cell line cells suppresses cell proliferation, changes cell morphology, and increases alkaline phosphatase activity, which is one of markers for differentiation of osteoblasts.
Claims13
An isolated nucleic acid encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
An isolated nucleic acid encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:1.
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO:3.
An isolated nucleic acid that hybridizes under stringent conditions to a single stranded nucleic acid consisting of the region within SEQ ID NO:3 that encodes SEQ ID NO:1.
Dependencies are inferred from the claim text.