Enzyme cleavable linker bound to solid phase for organic compound synthesis

A process for preparing a composition comprising a solid phase having a bound enzyme cleavable linker on which synthesis of an organic product takes place, said linker containing a functional group to which a synthesized product is bound when synthesis of the product takes place, and a hydrolytic enzyme recognition site and a fragmentation site different from the recognition site such that the linker is fragmented at the fragmentation site upon reaction of the recognition site with a hydrolytic enzyme to release a synthesized product from the linker without the product containing any of the linker, said composition having formula I

• wherein
• {circle around (P)} is a solid phase;
• Ŝ is a spacer with the length equivalent to 1 to 30 methylene groups;
• R is hydrogen or an inert radical, or two adjacent inert radicals R which together form an aromatic, heteroaromatic or aliphatic ring;
• n is 1or 2;
• R1 is substituted or unsubstituted C1-C20alkyl, C3-C20-alkenyl, C3-C6-alkynyl, Cl1-C20-alkylcarbonyl, C1-C20-alkylphosphoryl, C3-C20-alkenylcarbonyl, C3-C6-alkynylcarbonyl, C3-C20-alkenylphosphoryl, C3-C6-alkynylphosphoryl, C3-C20-cycloalkyl, C3-C20-cycloalkylcarbonyl, C3-C20-cycloalkylphosphoryl, aryl, arylcarbonyl, hetaryl, hetarylcarbonyl, hetarylphosphoryl, glycosyl, substituted or unsubstituted amino acids or peptides;
• and
• R2 is a nucleofugic group.
• which process comprises the steps of linking to a solid phase via a spacer a compound of formula II
• where X is COO, O NR3, S, OPO(OR4)—O, where R3 and R4 are, independently of one another, hydrogen or C1-C8-alkyl, wherein said linking via said spacer is via a linkage selected from the group consisting of ester, ether, amide, amine, sulfide and phosphate, and subsequently reacting the product formed with a compound of the formula III
• where Y and R2 are identical or different nucleofugic groups.