Use of idebenone and analogues against β amyloid induced cytotoxicity
AssigneeTakeda Chemical Industries, Ltd.
InventorsMasaomi Miyamoto, Keisuke Hirai, Giichi Goto
Life of this patent
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Abstract
A compound of the formula: wherein R1 represents a lower alkyl; R2 represents H, an optionally substituted alkyl or an optionally substituted alkenyl; R3 and R4 each represents an optionally substituted lower alkyl or a lower alkoxy, or R3 and R4 form, taken together, an optionally substituted butadienylene; and X1 and X2 each represents an optionally esterified or etherified hydroxy, or a salt thereof is useful for protecting cells from the cytotoxicity of β-amyloid protein.
Claims10
A method of protecting cells from the cytotoxicity of β-amyloid protein in a mammal, which comprises administering to such mammal an effective amount of a compound of the formula:
- wherein R1 represents a lower alkyl;
- R2 represents a hydrogen, an optionally substituted alkyl or an optionally substituted alkenyl;
- R3 and R4 each represents an optionally substituted lower alkyl or a lower alkoxy, or R3 and R4 form, taken together, a butadienylene;
- and
- X1 and X2 each represents an optionally esterified or etherified hydroxy, or a salt thereof with a pharmaceutically acceptable excipient, carrier or diluent.
A method for the treatment of Huntington's chorea or Creutzfeldt-Jacob disease, which comprises administering to a mammal an effective amount of a compound or the formula:
- wherein R1 represents a lower alkyl;
- R2 represents a hydrogen, an optionally substituted alkyl or an optionally substituted alkenyl;
- R3 and R4 each represents and optionally substituted lower alkyl or a lower alkoxy, or R3 and R4 form, taken together, a butadienylene;
- and
- X1 and X2 each represents an optionally esterified or etherified hydroxy, or
- salt thereof with a pharmaceutically acceptable excipient, carrier or diluent by protecting cells from the cytotoxicity of β-amyloid protein in such mammal.
Dependencies are inferred from the claim text.