Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
AssigneeGelTex Pharmaceuticals, Inc.
InventorsPradeep K. Dhal, Steven C. Polomoscanik
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Abstract
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise spirobicyclic ammonium moieties and optionally, further comprise a hydrophobic substituent, a quaternary ammonium-containing substituent or a combination thereof.
Claims22
A method for removing bile acids from a patient comprising administering to said patient a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer, copolymer or salt thereof comprising a repeat unit having the structural formula:
- wherein
- Y is a negatively-charged counter ion;
- m is a integer from zero to about seven;
- and
- Ring A and Ring B are each, independently, substituted or unsubstituted.
A method for removing bile acids from a patient, comprising administering to said patient a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer, copolymer or salt thereof comprising a repeat unit having the structural formula:
- wherein Y is a negatively-charged counter ion.
A method for removing bile acids from a patient, comprising administering to said patient a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer, copolymer or salt thereof comprising a repeat unit having the structural formula:
- wherein R1 and R2 can each independently be hydrogen, a C1-C30 aliphatic group, C1-C30 alkyl group, an aromatic group, a quaternary ammonium-containing group or a hydrophobic group, and Y is a negatively-charged counter ion.
Dependencies are inferred from the claim text.