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AssigneeIto En, Ltd.
InventorsTakami Kakuda, Ayumu Nozawa, Takanobu Takihara, Iwao Sakane, Yoichiro Kuroda, Kazuo Kobayashi, Masahiro Kawahara, Akihiro Mizutani, Kazuyo Muramoto, Kunihiko Umezawa
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This invention is characterized by a brain function improving preparation containing theanine not less than 50 μM. It was confirmed that theanine could increase intracellular Ca2+ concentration by acting on NMDA receptors even at a low dose of about 50 μM. Thus, the brain function improving preparation of this invention was shown to be capable of causing plastic change in neurons or neural circuit. Since theanine has been approved as a food additive and being consumed daily, its safety has no problem. Moreover, theanine passes the blood-brain barrier relatively easily and, thus, it is effective as an oral preparation.
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Dependencies are inferred from the claim text.