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US 6,271,245 B1Granted
Hydroxamic acid derivatives
AssigneeGuilford Pharmaceuticals Inc.
InventorsPaul F. Jackson, Kevin L. Tays, Keith M. MacLin, Barbara S. Slusher
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Abstract
The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
Claims11
A compound of formula I:
- or a pharmaceutically acceptable salt or hydrate thereof, wherein:
- X is
- Y is, NR3 or O;
- R, and R3 are independently selected from the group consisting of hydrogen, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl and Ar;
- and
- Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 2-indolyl, 3-indolyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, benzyl and phenyl, said Ar having one to three substituent(s) independently selected from the group consisting of hydrogen, halo, hydroxy, nitro, trifluoromethyl, C1-C6 straight or branched chain alkyl, C2-C6 straight or branched chain alkenyl, C1-C4 alkoxy, C2-C4 alkenyloxy, phenoxy, benzyloxy and amino.
3 more elements
Dependencies are inferred from the claim text.