Pharmaceutical composition

A method for reducing the side effects of active components administered to a diabetic patient, which comprises administering to said patient a therapeutically effective amount of a compound represented by the formula:

• wherein R′ represents an optionally substituted hydrocarbon or heterocyclic group;
• Y represents a group represented by —CO—, —CH(OH)— or —NR3— wherein R3 represents an optionally substituted alkyl group;
• m is 0 or 1;
• n is 0, 1 or 2;
• X represents CH or N;
• A represents a bond or a C1-7 divalent aliphatic hydrocarbon group;
• Q represents an oxygen atom or sulfur atom;
• R1 represents hydrogen atom or an alkyl group;
• ring E may optionally have 1 to 4 further substituents, and the substituents may optionally be combined with R1 to form a ring;
• L and M respectively represent a hydrogen atom, or L and M may optionally be combined with each other to form a bond;
• with a proviso that R′ does not represent benzopyranyl group when m and n are 0, X represents CH, A represents a bond, Q represents sulfur atom, R1, L and M represent hydrogen atoms and ring E does not have further substituents;
• or a pharmacologically acceptable salt thereof, in combination with an insulin preparation as said active components.