Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia

A method of treating glaucoma, ocular hypertension, ocular ischemia and related disorders in a patient with one or more of such conditions, comprising administering to said patient a composition comprising an ophthalmically effective amount of a compound of formula:

• wherein R1 represents a hydrogen atom, a chlorine atom or a hydroxyl group;
• and
• when
• R1 represents a hydrogen atom,
• A represents an ethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, a phenyl group or a benzyl group, R2 and R3 are directly bonded with each other, thereby forming a trimethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, a phenyl group or a benzyl group, and
• R4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms;
• with the proviso that the following compound be excluded:
• when
• R1 represents a chlorine atom or a hydroxyl group,
• A represents an alkylene group having 2 to 6 carbon atoms, said group being unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms,
• R2 and R3 are not bonded with each other and each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or R2 and R3 are directly bonded with each other, thereby forming an ethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms or a trimethylene group unsubstituted or substituted with alkyl group having 1 to 6 carbon atoms, and
• R4 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an amidino group;
• and pharmaceutically acceptable salts thereof;
• and an ophthalmically acceptable carrier therefore.