Anti-angiogenic agents
AssigneeAllergan Sales, Inc.
InventorsMichael E. Garst, Timothy L. MacDonald
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Abstract
The application discloses methods of treating mammalian diseases characterized by undesirable angiogenesis by administering compounds including those having the general formulae wherein A is a fused tropone having a general formula: wherein X is selected from the group consisting of hydrogen, hydroxy, carboxy, halogen, nitro, C1 to C12 alkenyl, C1 to C12 alkyl, C1 to C12 alkoxy, SR, NR2, OSO3−, OSO2NR2, HNSO3−, NHSO2NR2, SSO3−, SSO2NR2, wherein R is hydrogen or a C1 to C6 alkyl and the 17-ester and keto derivatives thereof, in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the method of the invention.
Claims6
A method for treating a mammalian disease characterized by undesirable angiogenesis, said method comprising administering to a mammal having said undesirable angiogenesis a compound of the formula below, said compound being administered in an amount sufficient to inhibit angiogenesis:
- wherein A is a fused tropone having a general formula:
- wherein X is selected from the group consisting of H, Cl, Br, methoxy and ethoxy.
A compound for treating a mammalian disease characterized by undesirable angiogenesis, of the formula below:
- wherein A is a fused tropone having a general formula:
- wherein X is selected from the group consisting of H, Cl, Br, methoxy and ethoxy.
A method for treating a mammalian disease characterized by undesirable angiogenesis, said method comprising administering to a mammal having said undesirable angiogenesis, a compound of the formula below, said compound being administered in an amount sufficient to inhibit angiogenesis:
- wherein A is
- and X is selected from the group consisting of chloro and bromo.
A method for treating a mammalian disease characterized by undesirable angiogenesis, said method comprising administering to a mammal having said undesirable angiogenesis, a compound of the formula below, said compound being administered in an amount sufficient to inhibit angiogenesis:
- wherein A is
- and X is methoxy.
A compound for treating a mammalian disease characterized by undesirable angiogenesis, of the formula below:
- wherein A is
- and X is selected from the group consisting of chloro and bromo.
A compound for treating a mammalian disease characterized by undesirable angiogenesis, of the formula below
- wherein A is
- and X is methoxy.
Dependencies are inferred from the claim text.