Method for inhibiting deoxyribonucleotide triphosphate biosynthesis
AssigneePrevisan S.A.
InventorsMichel Vandevelde, Hélène Margery
Life of this patent
Estimating the term…
Abstract
Process for inhibiting deoxyribonucleotide triphosphate biosynthesis by cells, comprising application onto these cells of at least one of the azo derivatives of the formula (I), in which R1, R2, R3 and R4=H, Hal, aliphatic or aromatic hydrocarbon or a nitro group, R1 and R2 as well as R3 and R4 being capable of forming a heterocyclic ring with the N adjacent thereto, X1 and X2=0 or NR5, where R5=H, Hal, aliphatic or aromatic hydrocarbon, or a nitro group, and the use of these derivatives for the production of medicines to be administered in conditions which require abnormal production of DNA from the cells
Claims19
Process for inhibiting deoxyribonucleotide triphosphate biosynthesis by cells, comprising application onto said cells of at least one of the azo derivatives of the formula
- in which R1, R2, R3 and R4 are identical or different and each represent a hydrogen or halogen atom or an optionally substituted aliphatic or aromatic hydrocarbon residue, R1 and R2 possibly being connected together to form a heterocyclic nucleus with the nitrogen atom adjacent thereto, and R3 and R4 possibly being connected together to form a heterocyclic nucleus with the nitrogen atom adjacent thereto, X1 and X2 are identical or different and each represent an oxygen atom or a group NR5, in which R5 is a hydrogen or halogen atom, an optionally substituted aliphatic or aromatic hydrocarbon residue, or a nitro group, and in which, when two groups NR5 are simultaneously present, each R5 may be identical to or different from the other, as well as the isomers thereof.
Method for therapeutic treatment of a human or animal body exhibiting abnormal cellular production of deoxyribonucleic acid, with the exception of those affected by a viral disease, comprising the stage of administration of a therapeutically effective quantity of an active substance to said human or animal body, this active substance being selected from among one or more of the azo derivatives of the formula
- in which R1, R2, R3 and R4 are identical or different and each represents a hydrogen or halogen atom or an optionally substituted aliphatic or aromatic hydrocarbon residue, R1 and R2 possibly being connected together to form a heterocyclic nucleus with the nitrogen atom adjacent thereto, and R3 and R4 possibly being connected together to form a heterocyclic nucleus with the nitrogen atom adjacent thereto, X1 and X2 are identical or different and each represents an oxygen atom or a group NR5, in which R5 is a hydrogen or halogen atom, an optionally substituted aliphatic or aromatic hydrocarbon residue, or a nitro group, and in which, when two groups NR5 are simultaneously present, each R5 may be identical to or different from the other, as well as from among the isomers thereof.
Dependencies are inferred from the claim text.