Stable solution of hyaluronate in a balanced salt medium
AssigneeAllergan, Inc.
InventorsRobert J. Mello, William P. Tew, Narlin B. Beaty
Life of this patent
Estimating the term…
Abstract
A stable physiologic balanced salt solution of a hyaluronate salt, such as sodium hyaluronate, is provided which contains calcium ion, for example, in the form of calcium chloride or calcium acetate, and magnesium ion, for example in the form of magnesium chloride or magnesium acetate, together with sodium chloride, potassium chloride or potassium acetate, sodium acetate, sodium citrate and water, and optionally bicarbonate, dextrose and glutathione disulfide, preservatives and other conventional ingredients employed in irrigating solutions. This solution is used as a visco-elastic ophthalmic device during ophthalmic surgery.
Claims19
A physiological visco-elastic formulation consisting of sodium hyaluronate in an amount in the range of about 0.1% to about 5% by weight in a balanced salt aqueous solution consisting of calcium ions present in a concentration in the range of about 2.6 mM to about 3.9 mM, magnesium ions present in a concentration in the range of about 1.2 mM to about 1.8 mM, potassium ions, chloride ions, acetate ions, citrate ions and sodium ions, other than sodium present as sodium hyaluronate, present in a concentration in the range of about 90 mM to about 110 mM, said formulation being ionically and osmotically balanced and being free of phosphates.
A physiological visco-elastic formulation consisting of sodium hyaluronate in an amount in the range of about 0.1% to about 5% by weight in an osmotically balanced salt aqueous solution consisting of chloride ions in a concentration in the range of about 59 mM to about 89 mM, potassium ions in a concentration in the range of about 8 mM to about 12 mM, calcium ions in a concentration in the range of about 2.6 mM to about 3.9 mM, magnesium ions in a concentration in the range of about 1.2 mM to about 1.8 mM, acetate ions in a concentration in the range of about 23 mM to about 34 mM, citrate ions in a concentration in the range of about 4.6 mM to about 6.9 mM, and sodium ions, other than sodium present as sodium hyaluronate, present in a concentration in the range of about 90 mM to about 110 mM, said formulation being free of phosphates.
Dependencies are inferred from the claim text.