Process for the preparation of immunomodulatory polysaccharides from aloe
AssigneeUnivera Pharmaceuticals, Inc.
InventorsZhihua Qiu, Belaid Mahiou
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Abstract
The present invention provides a rapid and efficient method for the preparation and isolation of biologically active polysaccharides from Aloe. The present invention includes the activated mixture of polysaccharides (referred to herein as “Inmuno-10”), produced by the methods of the invention. The invention also includes the use of the polysaccharides as immunostimulating, immunomodulating and wound healing agents. The resulting immunomodulatory complex has a higher activity and is more stable than bulk carbohydrates isolated using prior art alcohol precipitation schemes.
Claims2
The use of a composition as an immunostimulating, immunomodulating or wound healing agent comprising administering an effective amount of said composition to a patient in need thereof, said composition having the following characteristics:
- (a) comprised primarily (>95%) of polysaccharides derived from Aloe, said polysaccharides in said composition having an average molecular weight of 70-80 kDa with a range between 50-200 kDa;
- (b) said polysaccharides are comprised of D-galactose (approx. 5% or less), D-glucose (approx. 5% or less) and D-mannose (approximately 90%);
- (c) said polysaccharides are comprised of monosaccharides having primarily β-1,4 linkages;
- and
- (d) said polysaccharides are highly acetylated having approximately 1 acetyl group per monosaccharide, wherein said acetyl group is on the 2, 3 or 6 position of the monosaccharide unit.
A method of treating immunodeficiency or immune-suppressing diseases by administering to a person in need thereof a composition having the following characteristics:
- (a) comprised primarily (>95%) of polysaccharides derived from Aloe, said polysaccharides in said composition having an average molecular weight of 70-80 kDa with a range between 50-200 kDa;
- (b) said polysaccharides are comprised of D-galactose (approx. 5% or less), D-glucose (approx. 5% or less) and D-mannose (approximately 90%);
- (c) said polysaccharides are comprised of monosaccharides having primarily β-1,4 linkages;
- and
- (d) said polysaccharides are highly acetylated having approximately 1 acetyl group per monosaccharide, wherein said acetyl group is on the 2, 3 or 6 position of the monosaccharide unit.
Dependencies are inferred from the claim text.