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AssigneeAlbert Einstein College of Medicine of Yeshiva University
InventorsGeorge J. Christ, Arnold Melman
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The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.
A method for treating penile flaccidity caused by heightened contractility of penile smooth muscle in a subject, comprising introducing directly into penile smooth muscle cells of the subject a DNA sequence comprising a promoter sequence operably linked to a sequence encoding a KATP channel subunit protein, wherein the channel subunit protein is Kir6.2, and wherein said Kir6.2 is expressed in said penile smooth muscle cells such that penile smooth muscle tone is regulated, and wherein the regulation of penile smooth muscle tone results in less heightened contractility of penile smooth muscle in said subject.
Dependencies are inferred from the claim text.