Antisense oligonucleotides for mitogen-activated protein kinases as therapy for cancer
AssigneeThe Research Foundation of SUNY
InventorsVimala S. Sivaraman, Hsien-yu Wang, Craig C. Malbon
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Abstract
A method is disclosed for inhibiting malignant neoplastic growth of epithelial or endothelial cells in a mammal by administering to the mammal an effective amount of an oligonucleotide complementary to at least a portion of mRNA for ERK-1 or ERK-2 that is overexpressed in the mammal. The antisense oligonucleotides are administered to the mammal as a dosage unit. A method of identifying and monitoring potentially malignant neoplastic cell growth in a mammal is also disclosed.
Claims6
A method of inhibiting growth of malignant lung tumors in a mammal, which comprises injecting directly into the tumor or administering to the lung of said mammal in an aerosolized form an effective amount of an oligonucleotide having 10-100 nucleotides and complementary to the initiation region of ERK-1 or ERK-2.
Dependencies are inferred from the claim text.