Process of making cationic lipid-nucleic acid complexes
AssigneeTransgene S.A.
InventorRainer Bischoff
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Abstract
The invention is related to a method for preparing an homogenous suspension of stable lipid-nucleic acid complexes or particles, comprising: a) combining one or more cationic lipids, one or more colipids, and one or more stabilizing additives to form a lipid suspension, b) combining the lipid suspension with a nucleic acid to form a complex or a particle, and optionally c) subjecting the complex or particle to a sizing procedure. It also concerns an homogenous suspension produced notably by the above method.
Claims35
A method for preparing an homogenous suspension of stable lipid-nucleic acid complexes or particles, comprising:
- a) combining one or more cationic lipids, one or more colipids, and one or more stabilizing additives to form a lipid suspension,
- b) combining the lipid suspension with a nucleic acid to form a complex or a particle, and optionally
- c) subjecting the complex or particle to a sizing procedure.
An homogenous suspension of stable lipid-nucleic acid complexes or particles, produced by:
- a) combining one or more cationic lipids, one or more colipids, and one or more stabilizing additives to form a lipid suspension,
- b) combining the lipid suspension with a nucleic acid to form a complex or a particle, and optionally
- c) subjecting the complex or particle to a sizing procedure.
A lipid-nucleic acid complex comprising one or more cationic lipids, one or more colipids, one or more stabilizing additives, and a nucleic acid component.
Dependencies are inferred from the claim text.