Cancer treatment by expression of differentiation factor receptor
AssigneesUniversity of Massachusetts Medical Center, Worcester Foundation for Biomedical Research
InventorsAlonzo H. Ross, Lawrence D. Recht, Mahesh B. Lachyankar
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Abstract
Disclosed are methods of reducing or inhibiting the motility and/or proliferative abilities of a neural tumor cell, or of enhancing apoptosis or differentiation of the tumor cell, in which a vector comprising a nucleic acid encoding a cytoplasmic domain of a neurotrophin receptor tyrosine kinase, is transferred to the tumor cell such that the nucleic acid is expressed. The methods of the invention result in reduced tumorigenicity of neural tumors.
Claims11
A method of treating a neurological tumor in a mammal, the method comprising:
- (a) providing a vector comprising a first nucleic acid encoding an intracellular domain of a tyrosine kinase receptor for a neurotrophin and a second nucleic acid encoding an extracellular domain of a tyrosine kinase receptor, wherein the second nucleic acid is in operative association with the first nucleic acid;
- and
- (b) administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising the vector and a physiologically acceptable carrier, wherein the nucleic acids encoding the intracellular domain of the receptor and the extracellular domain of the receptor are expressed in the tumor.
Dependencies are inferred from the claim text.