Constrained helical peptides and methods of making same

A compound selected from the group consisting of:

• the compound represented by Formula (1):
• wherein S is absent or is a macromolecule, X is hydrogen or is any amino acid or amino acid sequence, Y is absent, or is hydroxyl if S is absent, or is any amino acid or amino acid sequence, m and p are independently selected from the integers 0 to 6 inclusive, provided that m+p is less than or equal to 6, and n is any integer in the range defined by (7−(m+p)) to (9−(m+p)) inclusive, provided that n is greater than 1;
• the compound represented by Formula (6):
• wherein S is absent or is a macromolecule, X is hydrogen or is any amino acid or amino acid sequence, Y is absent, or is hydroxyl if S is absent, or is any amino acid or amino acid sequence, q is selected from the integers 1 to 7 inclusive, s is selected from the integers 0 to 6 inclusive, provided that q+s is less than or equal to 7, and r is any integer in the range defined by (7−(q+s)) to (9−(q+s)) inclusive, provided that r is greater than 0;
• the compound represented by Formula (11):
• wherein S is absent or is a macromolecule, X is hydrogen or is any amino acid or amino acid sequence, Y is absent, or is hydroxyl if S is absent, or is any amino acid or amino acid sequence, t is selected from the integer 0 to 6 inclusive, and v is selected from the integers 1 to 7 inclusive, provided that t+v is less than or equal to 7;
• and u is any integer in the range defined by (7−(t+v)) to (9−(t+v)) inclusive, provided that u is greater than 0;
• and
• the compound represented by Formula (16):
• wherein S is absent or is a macromolecule, X is hydrogen or is any amino acid or amino acid sequence, Y is absent, or is hydroxyl if S is absent, or is any amino acid or amino acid sequence, w and y are independently selected from the integers 1 to 7 inclusive, provided that w+y is less than or equal to 8, and x is any integer in the range defined by (7−(w+y)) to (9−(w+y)) inclusive, provided that x is greater than or equal to 0,
• wherein Z is an amino acid sequence consisting of six amino acids, wherein the internal sequence of six amino acids has the form gabcde, defgab, or cdefga and is selected from the group of sequences consisting of a sequence of six contiguous amino acids in HIV-1LAI strain gp41 amino acid sequence 633 to 678, in its homolog sequence from another HIV strain, in a consensus sequence of its homolog sequences from any one HIV clade, and amino acid substituted variant thereof, in which amino acid 633 or its corresponding amino acid in the homolog, consensus or variant sequence is assigned position a of a repeating abcdefg assignment.