Methods of alleviating neuropathic pain using prosaposin-derived peptides
AssigneeThe Regents of the University of CA
InventorJohn S. O'Brien
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Abstract
The invention provides a method of alleviating neuropathic pain in a subject by administering an effective amount of an active fragment of prosaposin to the subject. The invention also provides a method of preventing neuropathic pain in a subject by administering an effective amount of an active fragment of prosaposin to the subject.
Claims7
A method for treating prosaposin-responsive neuropathic pain of the peripheral nervous system, comprising administering to a subject suffering from prosaposin-responsive neuropathic pain an effective amount of an active fragment of prosaposin comprising the active fragment located within SEQ ID NO:1;
- wherein the subject's perceived neuropathic pain is eliminated or reduced.
A method for treating prosaposin-responsive neuropathic pain of the peripheral nervous system, comprising administering to a subject suffering from prosaposin-responsive neuropathic pain, an effective amount of a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, and SEQ ID NO:7
- wherein the subject's perceived neuropathic pain is eliminated or reduced.
Dependencies are inferred from the claim text.