Methods for high throughout determination and ranking of formulations and solubility

A method for ranking the solubility of a chemical in a plurality of formulations, the method comprising:

• mixing a volume of a stock solution that has a known concentration of a chemical with a volume of a base liquid to form a control sample;
• mixing other volumes of the stock solution with volumes of multiple formulations to form multiple test samples;
• passing the control sample through a CEC tube to separate the chemical from the base liquid;
• passing the test samples through CEC tubes to separate the chemical from the formulations;
• measuring the amount of chemical passing through the CEC tubes for the control sample and the test samples;
• and
• comparing the measured amount of chemical from the control sample with the measured amount of chemical from each of the test samples to determine the solubility of the chemical in the formulations relative to the base liquid.

A method for ranking the solubility of a chemical in a plurality of formulations, the method comprising:

• (a) providing a substrate having multiple wells and fluid delivery channels, including a stock solution well and formulation wells;
• (b) placing a volume of a stock solution that has a known concentration of a chemical into the stock solution well;
• (c) placing a base liquid and different formulations into the formulation wells;
• (d) applying an electrical potential to mix a volume of the stock solution from the stock solution well with a volume of the base liquid from one of the formulation wells to form a control sample;
• (e) applying electrical potentials to mix other volumes of the stock solution from the stock solution wells with volumes of the formulations from the formulation wells to form multiple test samples;
• (f) applying electrical potentials to move the control sample and the test samples through at least some of the fluid channels and into and through CEC tubes;
• (g) measuring the amount of chemical passing through the CEC tubes for the control sample and the test samples;
• and
• (h) comparing the measured amount of chemical from the control sample with the measured amount of chemical from each of the test samples to determine the solubility of the chemical in the formulations relative to the base liquid.