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US 6,271,030 B1Granted
Antisense inhibition of C/EBP beta expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Madeline M. Butler, Jacqueline Wyatt
Life of this patent
Estimating the term…
Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of C/EBP beta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C/EBP beta. Methods of using these compounds for modulation of C/EBP beta expression and for treatment of diseases associated with expression of C/EBP beta are provided.
Claims13
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 18, 25, 28, 31, 33, 34, 36, 40, 41, 42, 45, 46, 50, 52, 54, 55, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 68, 69, 70, 71, 72, 73, 75, 79, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 100, 102, 105, 106, 114, 120, 121, 127, 128, 130, 132, 133, 138, 139, 142, 146, 147, 150, 153, 154, 158, 164, 165, 166, 167, 175, 176, 179, 182, 202, 203, 206, 209, 210, 211, 214, 216, 217, 218, 219, 221, 222, 232, 236, 237, 238, 239 or 240 which inhibits the expression of human or mouse C/EBP beta.
Dependencies are inferred from the claim text.