Antisense inhibition of cytohesin-2 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsC. Frank Bennett, Lex M. Cowsert
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of cytohesin-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cytohesin-2. Methods of using these compounds for modulation of cytohesin-2 expression and for treatment of diseases associated with expression of cytohesin-2 are provided.
Claims26
An antisense compound 15 to 30 nucleobases in length targeted to a nucleic acid molecule encoding human cytohesin-2, wherein said antisense compound specifically hybridizes with said nucleic acid molecule and inhibits the expression of human cytohesin-2.
An antisense compound up to 30 nucleobases in length comprising at least a 15-nucleobase portion of SEQ ID NO:
- 12, 14, 15, 18, 19, 20, 21, 22, 23, 25, 26, 27, 29, 31, 32, 35, 36, 37, 39, 40, 42, 43, 45, 46, 48, 49, 50, 51, 53, 54, 56, 57, 58, 59, 60, 61, 62, 65, 66, 67, 68, 69, 70, 71, 73, 76, 77, 79, 80, 81, 83, 84, 87, 88 or 89 which inhibits the expression of human cytohesin-2.
Dependencies are inferred from the claim text.