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US 6,271,028 B1Granted
Hematopoietic cell method for treatment of HIV infection
OwnerFrancis E. O'Donnell, Jr.inventor
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Abstract
The risk of drug resistance in HIV infection is reduced by profoundly suppressing the viral load using novel hematopoietic cells. Modified CD4 lymphocyte host cells are used to “capture” virions in a sterile micro-environment. The host's CD4 T-cell lymphocytes are replaced with lumphocytes derived from autologous or homologous stem cells which do not express the CKR-5 receptor, further inhibiting viral load.
Claims11
A method of preparing host cells that are substantially devoid of infrastructure required for viral replication which comprises:
- (a) isolating mononuclear target cells from a host;
- (b) performing in vitro treatment of the target cells with a multi-drug array of antivirals and/or ionizing radiation chemotherapy to render the target cells' replicative infrastructure substantially ineffective;
- and
- (c) harvesting the resulting autologous lymphocytes and lymphocytic stem cells.
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Dependencies are inferred from the claim text.