Leukemia associated genes
AssigneeLudwig Institute for Cancer Research
InventorsNicolas Van Baren, Pierre G. Coulie, Charles DeSmet, Sophie Lucas, Thierry Boon-Falleur
Life of this patent
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Abstract
The invention describes leukemia associated genes, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a preproTRH, tryptase-L and/or Oct-T1 gene product.
Claims19
A kit for detecting the presence of the expression of a leukemia associated polypeptide precursor comprising a pair of isolated nucleic acid molecules each of which consists essentially of a molecule selected from the group consisting of (a) a 12-32 nucleotide contiguous segment of SEQ ID NO:1, (b) a 12-32 nucleotide contiguous segment of SEQ ID NO:3, (c) a 12-32 nucleotide contiguous segment of SEQ ID NO:5, (d) a 12-32 nucleotide contiguous segment of SEQ ID NO:7, (e) complements of “(a)”, (f) complements of “(b)”, (g) complements of “(c)”,and (h) complements of “(d)”, wherein the contiguous segments are nonoverlapping.
An isolated nucleic acid molecule selected from the group consisting of:
- (a) nucleic acid molecules selected from the group consisting of SEQ ID NO:3 and SEQ ID NO:5, which code for a tryptase-L leukemia associated polypeptide,
- (b) nucleic acid molecules that differ from the nucleic acid molecules of (a) in codon sequence due to the degeneracy of the genetic code, and
- (c) complements of (a) and (b).
An isolated nucleic acid molecule selected from the group consisting of:
- (a) a fragment of nucleotides 487-1499 of SEQ ID NO:3 between 12 and 1012 nucleotides in length,
- (b) a fragment of nucleotides 487-1499 of SEQ ID NO:5 between 12 and 1012 nucleotides in length,
- (c) a fragment of nucleotides 1665-1774 of SEQ ID NO:5 between 12 and 109 nucleotides in length, and
- (d) complements of (a), (b), and (c).
Dependencies are inferred from the claim text.