VEGF-binding polypeptide
AssigneeToa Gosei Co., Ltd.
InventorsMasabumi Shibuya, Masaji Okamoto, Mikio Niwa, Tomoe Matsumoto, Makoto Asano, Tosiaki Segawa
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Abstract
An object of the present invention is to provide a low molecular weight VEGF inhibitor that can be utilized to treat diseases accompanying neovascularization, such as solid tumors. It was found that a polypeptide containing immunoglobulin-like domain 1 and immunoglobulin-like domain 2 but neither immunoglobulin-like main 6 nor immunoglobulin-like domain 7 of the extracellular domain of the VEGF receptor FLT possess VEGF inhibitory activity.
Claims11
A DNA encoding a polypeptide consisting of immunoglobulin-like domains 1 and 2 of FLT-1, and optionally (a) a portion of immunoglobulin-like domain 3 of FLT-1, (b) a signal sequence of FLT-1, or (c) a portion of immunoglobulin-like domain 3 of FLT-1 and the signal sequence of FLT-1, said polypeptide being capable of inhibiting an activity of vascular endothelial call growth factor (VEGF) by binding to VEGF.
A DNA encoding a polypeptide consisting of immunoglobulin-like domain 1, immunoglobulin-like domain 2 and a portion of immunoglobulin-like domain 3 of SEQ ID NO:
- 24, said polypeptide being capable of inhibiting an activity of VEGF by binding to VEGF.
A DNA encoding a polypeptide consisting of a signal sequence, immunoglobulin-like domain 1, immunoglobulin-like domain 2, and a portion of immunoglobulin-like domain 3 of SEQ ID NO:24, said polypeptide being capable of inhibiting an activity of VEGF by binding to VEGF.
Dependencies are inferred from the claim text.