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US 6,270,803 B1Granted
Controlled-release garlic formulations
AssigneeBio-Dar Ltd.
InventorsYoav Blatt, David Cohen, Eugene Kimmelman, Oded Friedman, Avner Rotman
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AssigneeBio-Dar Ltd.
InventorsYoav Blatt, David Cohen, Eugene Kimmelman, Oded Friedman, Avner Rotman
Estimating the term…
There are provided orally-administrable formulations for the controlled release of granulated garlic, comprising particles of granulated garlic coated with a film comprising a mixture of at least one water soluble polymer and at least one water insoluble polymer, said at least one water soluble polymer and at least one water insoluble polymer being present in a ratio that produces a substantially zero order linear release pattern of at least one active ingredient. Preferably, the formulations are characterized in that the total in vitro dissolution time of said formulations required for release of 75% of the Allicin available from said formulations based upon the total amount of alliin initially present in said formulations is between about 4 and about 12 hours, as determined by U.S.P. XXIII paddle method at a paddle speed of 150 rpm, using simulated intestinal fluid without the digestive enzymes normally found in intestinal fluid, containing 0.1% w/w sodium dodecyl sulfate (SDS), at pH 6.8, and a temperature of 37° C. A process for preparing the formulations of the invention is also disclosed.
An orally-administrable formulation for the controlled release of granulated garlic, consisting essentially of microencapsulated granulated garlic particles which have been microencapsulated by direct coating with an enteric coating and at least one pharmaceutically acceptable diluent, adjuvant or excipient therefor.
A process for the preparation of an orally-administrable formulation for the controlled release of granulated garlic, said preparation comprising microencapsulated granulated garlic particles which have been microencapsulated by being directly coated with an enteric coating and at least one diluent, adjuvant or excipient therefor, said process comprising the steps of:
An orally-administrable formulation for the controlled release of granulated garlic, consisting essentially of particles of granulated garlic directly coated with a film comprising a mixture of at least one water soluble polymer and at least one water insoluble polymer, said at least one water soluble polymer and at least one water insoluble polymer being present in a ratio that produces a substantially zero order linear release pattern of at least one active ingredient.
An orally-administrable formulation for the controlled release of granulated garlic, consisting essentially of particles of granulated garlic directly coated with an enteric coating comprising a polymer film comprising a polymer which is insoluble at a pH below about 5.5.
A process for producing an orally-administrable formulation for the controlled release of granulated garlic, comprising microencapsulating granulated garlic particles by directly coating said granulated garlic particles with an inner, mixed polymer film comprising ethyl cellulose and hydroxypropylmethyl cellulose (HPMC), wherein the HPMC/ethyl cellulose ratio is substantially from about 0 to about 0.40 by weight, and then coating said particles coated with said inner polymer film with an outer polymer film comprising hydroxypropylmethyl cellulose phthalate, wherein the weight ratio of the outer and inner polymer layers is between about 0.5 to 1.5.
Dependencies are inferred from the claim text.