Conserved metalloprotease epitopes
AssigneeUniversity Technologies International Inc.
InventorsPamela A. Sokol, Cora D. Kooi
Life of this patent
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Abstract
The present invention provides immunogenic compositions comprising peptides derived from the amino acid sequence of P. aeruginosa for protecting susceptible hosts against diseases caused by bacterial pathogens which secrete a zinc metalloprotease.
Claims15
A peptide consisting of the amino acid sequence VSHGFTEQNSGLIYRGQSGGMNEAF (Sequence ID No:
- 1) or a fragment or conservative amino acid substitution variant thereof, which contains an epitope which is recognized by an antibody which neutralizes the proteolytic activity of Pseudomonas aeruginosa.
A peptide consisting of the amino acid sequence HGFTEQNSG (Sequence ID No:3).
A peptide consisting of the amino sequence SGALRYMDQPSRDGRSIDM (Sequence ID No:
- 11) or a fragment or conservative amino acid substitution variant thereof, which contains an eptitope which is recognized by an antibody which neutralizes the proteolytic activity of Pseudomonas aeruginosa.
A peptide consisting of the amino acid sequence RYMDQPSRD (Sequence IN No:14).
An immunogenic composition comprising at least one active component selected from the group consisting of:
- (a) a peptide consisting of the amino acid sequence HGFTEQNSG (Sequence ID No:3);
- (b) a peptide consising of the amino acid sequence RYMDQPSRD (Sequence ID No:4);
- (c) a peptide consisting of the amino acid sequence VSHGFTEQNSGLIYRGQSGGMNEAF (Sequence ID No:1);
- (d) a peptide consisting of the amino acid sequence SGALRYMDQPSRIDGRSIDM (Sequence ID No.:11);
- and
- (e) a fragment or conservative amino acid substitution variant of a peptide of (a), (b), (c) or (d), which contains a epitope which is recognized by an antibody which neutralizes the proteolytic activity of Pseudomonas aeruginosa
- and a pharmaceutically acceptable carrier, said at least one active component producing an immune response when administered to a host.
Dependencies are inferred from the claim text.