Streptococcal C5a peptidase vaccine

A method of protecting a susceptible mammal against β-hemolytic Streptococcus colonization or infection comprising administering to the mammal an effective amount of a vaccine comprising an immunogenic amount of an enzymatically inactive streptococcal C5a peptidase (SCP) peptide, wherein the peptide includes the catalytic domain of SCP, which amount is effective to prevent or ameliorate Streptococcus colonization or infection in the susceptible mammal in combination with a physiologically-acceptable, non-toxic vehicle.

A vaccine comprising an immunogenic amount of an enzymatically inactive peptide comprising the catalytic domain of streptococcal C5a peptidase (SCP), wherein the peptide is capable of generating antibody specifically recognizes a streptococcal C5a peptidase (SCP), and wherein the amount is effective to prevent or ameliorate β-hemolytic Streptococcus colonization or infection in a susceptible mammal in combination with a physiologically-acceptable, non-toxic vehicle.

A method of protecting a susceptible mammal against β-hemolytic Streptococcus colonization or infection comprising administering to the mammal an effective amount of vaccine comprising an immunogenic amount of an enzymatically inactive peptide comprising the catalytic domain of streptococcal C5a peptidase (SCP), wherein the peptide is capable of generating antibody specific to streptococcal C5a peptidase (SCP), and wherein the amount is effective to prevent or ameliorate β-hemolytic Streptococcus colonization or infection in a susceptible mammal in combination with a physiologically-acceptable, non-toxic vehicle.

A vaccine comprising an immunogenic amount of an enzymatically inactive peptide comprising an epitope of the catalytic domain of streptococcal C5a peptidase (SCP), wherein the peptide is capable of generating antibody that specifically recognizes a streptococcal C5a peptidase (SCP), and wherein the amount is effective to prevent or ameliorate β-hemolytic Streptococcus colonization or infection in a susceptible mammal in combination with a physiologically-acceptable, non-toxic vehicle.