Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
AssigneeInstitut Pasteur
InventorsClaudine Guerin-Marchand, Pierre Druilhe
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Abstract
The invention discloses a molecule or polypeptide composition characterized by the presence in its structure of one or more peptide sequences bearing all or part of one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of proteins resulting from the infectious activity of P. Falciparum in hepatic cells. Also disclosed is the use of these molecules in tests, and a kit for in vitro diagnosis of paludism from a biological sample from the individual in whom the disease is to be detected.
Claims9
A polypeptide consisting of an amino acid sequence of SEQ ID NO. 19 or an epitope effective portion.
An in vitro method for detecting malaria in an individual infected by Plasmodium falciparum which comprises placing a tissue or a biological fluid taken from said individual, in contact with a polypeptide consisting of an amino acid sequence of SEQ ID NO. 19 or an epitope effective portion of SEQ ID NO. 19, under conditions allowing an in vitro immunological reaction to occur between said polypeptide and antibodies present in the biological fluid or tissue, and detecting antigen-antibody complexes formed thereby.
A kit for detecting malaria in an individual infected by Plasmodium falciparum which comprises a polypeptide consisting of an amino acid sequence of SEQ ID NO. 19 or an epitope effective portion of SEQ ID NO. 19.
Dependencies are inferred from the claim text.