Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
AssigneeThe Kennedy Institute of Rheumatology
InventorsMarc Feldman, Ravinder N. Maini
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Abstract
Methods for treating and/or preventing a TNF-mediated disease in an individual are disclosed. Also disclosed is a composition comprising methotrexate and an anti-tumor necrosis factor antibody. TNF-mediated diseases include rheumatoid arthritis, Crohn's disease, and acute and chronic immune diseases associated with transplantation.
Claims30
A method of treating arthritis in an individual in need thereof comprising co-administering methotrexate and an anti-tumor necrosis factor alpha antibody or an antigen-binding fragment thereof to the individual, in therapeutically effective amounts.
A method of treating rheumatoid arthritis in an individual in need thereof comprising co-administering methotrexate and an anti-tumor necrosis factor alpha antibody or an antigen-binding fragment thereof to the individual, in therapeutically effective amounts.
A method of treating Crohn's disease in an individual in need thereof comprising co-administering methotrexate and an anti-tumor necrosis factor alpha antibody or an antigen-binding fragment thereof to the individual, in therapeutically effective amounts.
A composition comprising methotrexate and an anti-tumor necrosis factor alpha antibody or an antigen-binding fragment thereof.
A method of treating arthritis in an individual in need thereof comprising co-administering to the individual, in therapeutically effective amounts, methotrexate and a soluble TNFα receptor or functional portion thereof, wherein said soluble TNFα receptor is selected from the group consisting of p55 TNFα receptor and p75 TNFα receptor.
Dependencies are inferred from the claim text.