Multi-well rotary synthesizer

A synthesizer for forming a polymer chain by sequentially adding monomer units found in a plurality of reagent solutions, the synthesizer comprising:

• a. a first vial for holding a selective one or more of the plurality of reagent solutions during synthesis;
• b. a second vial for holding a selective one or more of the plurality of reagent solutions during synthesis;
• c. a cartridge to hold the first vial and the second vial;
• d. a dispensing system to dispense the selective one or more of the plurality of reagent solutions into the first and second vials;
• e. a drain plate coupled to the cartridge including a first collection area having a first drain configured to collect material from the first vial and a second collection area having a second drain configured to collect material from the second vial;
• and
• f. a purging system including a waste tube to remove material from a selective one of the first vial and the second vial, wherein the waste tube is configured to selectively engage one of the first drain and the second drain corresponding to the selective one of the first vial and the second vial and purge material from the selective one of the first vial and the second vial when the waste tube engages the selective one of the first drain and the second drain, wherein in order to engage the first drain and the second drain a selective one or both of the waste tube and the selective one of the first drain and the second drain are moved in relation to each other.

A synthesizer for creating a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:

• a. a plurality of vials each for holding material including a selective one of the plurality of reagent solutions during synthesis;
• b. a cartridge for holding the plurality of vials and dividing the plurality of vials into a first bank of vials including at least one of the plurality of vials and a second bank of vials including at least one of the plurality of vials;
• c. a first drain configured to collect material from the first bank of vials;
• d. a second drain configured to collect material from the second bank of vials
• e. a dispensing system configured to sequentially dispense selective ones of the plurality of reagent solutions into the plurality of vials;
• and
• f. a purging system configured to purge material from a selective one of the first bank of vials and the second bank of vials, wherein the purging system includes a waste tube configured to mechanically engage a selective one of the first drain and the second drain corresponding to the selective one of the first bank vials and the second bank of vials to purge material from the selective one of the first bank of vials and the second bank of vials when the waste tube engages the selective one of the first drain and the second drain, wherein in order to engage the first drain and the second drain a selective one or both of the waste tube and the selective one of the first drain and the second drain are moved in relation to each other.

A synthesizer for forming a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:

• a. a cartridge configured to hold a first vial and a second vial, each for holding a selective one or more of the plurality of reagent solutions during synthesis;
• b. a drain plate coupled to the cartridge including a first collection area having a first drain configured to collect material from the first vial and a second collection area having a second drain configured to collect material from the second vial;
• c. a dispensing system configured to dispense the selective one or more of the plurality of reagent solutions into the first and second vials;
• and
• d. a purging system including a waste tube configured to expel material from a selective one of the first and second vials, wherein a selective one or both of the waste tube and the cartridge are moved in relation to each other in order to allow the purging system to engage a selective one of the first drain and the second drain corresponding to the selective one of the first vial and the second vial and thereby expel material from the selected one of the first vial and the second vial through the selective one of the first drain and the second drain and through the purging system when the selective one of the first drain and the second drain is engaged.

A synthesizer for forming a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising

• a. a first plurality of vials and a second plurality of vials, each of the vials for holding a selective one or more of the plurality of reagent solutions during synthesis;
• b. means for dispensing configured for dispensing the selective one or more of the plurality of reagent solutions into the first plurality of vials and the second plurality of vials;
• c. a cartridge configured for holding the first plurality of vials in a first bank of vials and the second plurality of vials in a second bank of vials;
• d. a drain plate coupled to the cartridge including a first collection area having a first drain configured to collect material from the first bank of vials and a second collection area having a second drain configured to collect material from the second bank of vials;
• and
• e. means for expelling material from a selective one of the first bank of vials and the second bank of vials, configured for selectively engaging the first drain and the second drain corresponding to the selective one of the first bank of vials and the second bank of vials and thereby purging material from the selective one of the first bank of vials and the second bank of vials when the corresponding first drain and second drain is engaged.

A synthesizer for forming a polymer chain by sequentially adding monomer units found in a plurality of reagent solutions, the synthesizer comprising:

• a. a first plurality of vials each for holding a selective one or more of the plurality of reagent solutions during synthesis;
• b. a second plurality of vials each for holding a selective one or more of the plurality of reagent solutions during synthesis.
• c. a cartridge to hold the first plurality of vials in a first bank of vials and the second plurality of vials in a second bank of vials;
• d. a dispensing system to dispense the selective one or more of the plurality of reagent solutions into the first and second plurality of vials;
• e. a drain plate coupled to the cartridge including a first collection area having a first drain configured to collect material from the first bank of vials and a second collection area having a second drain configured to collect material from the second bank of vials;
• and
• f. a purging system to remove material from a selective one of the first bank of vials and the second bank of vials, wherein the purging system is configured to selectively engage the first drain and the second drain corresponding to the selective one of the first bank of vials and the second bank of vials and purge material from the selected one of the first bank of vials and the second bank of vials when the corresponding first drain and second drain is engaged.

A synthesizer for creating a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:

• a. a plurality of vials each for holding material including a selective one of the plurality of reagent solutions during synthesis;
• b. a cartridge for holding the plurality of vials and dividing the plurality of vail into a first bank of vials including two or more of the plurality of vials and a second bank of vials including two or more of the plurality of vials;
• c. a first drain configured to collect material from the first bank of vials;
• d. a second drain configured to collect material from the second bank of vials;
• e. a dispensing system configured to sequentially dispense selective ones of the plurality of reagent solutions into the plurality of vials;
• and
• f. a purging system configured to purge material from a selective one of the first bank of vials and the second bank of vials, wherein the purging system includes a waste tube configured to mechanically engage the selected one of the first drain and the second drain corresponding to the selective one of the first bank of vials and the second bank of vials to purge material from the selective one of the first bank of vials and the second bank of vials when the waste tube engages the selective one of the first drain and the second drain, wherein in order to engage the first drain and the second drain a selective one or both of the waste tube and the selective one of the first drain and the second drain are moved in relation to each other.

A synthesizer for forming a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:

• a. a cartridge configured to hold a first plurality of vials in a first bank of vials and a second plurality of vials in a second bank of vials, each of the vials for holding a selective one or more of the plurality of reagent solutions during synthesis;
• b. a drain plate coupled to the cartridge including a first collection area having a first drain configured to collect material from the first bank of vials and a second collection area having a second drain configured To collect material from the second bank of vials;
• c. a dispensing system configured to dispense the selective one or more of the plurality of reagent solutions into the first and second plurality of vials and
• d. a purging system configured to expel material from a selective one of the first bank of vials and the second bank of vials, wherein a selective one or both of the purging system and the cartridge are moved in relation to each other in order to allow the purging system to engage a selective one of the first drain and the second drain corresponding to the selective one of the first bank of vials and the second bank of vials and thereby expel material from the selected one of the first bank of vials and the second bank of vials through the selective one of the first drain and the second drain and through the purging system when the selective one of the first drain and the second drain is engaged.

A synthesizer for forming a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:

• a. a first vial and a second vial, each for holding a selective one or more of the plurality of reagent solutions during synthesis;
• b. means for dispensing configured for dispensing the selective one or more of the plurality of reagent solutions into the first and second vials;
• c. a cartridge configured for holding the first vial and the second vial;
• d. a drain plate coupled to the cartridge including a first collection area having a first drain configured to collect material from the first vial and a second collection area having a second drain configured to collect material from the second vial;
• e. means for expelling material from a selective one of the first and second vials, including means for collecting configured for selectively engaging one of the first drain and the second drain corresponding to the selective one of the first and second vials and thereby purging material from the selective one of the first vial and the second vial when the means for collecting engages the selective one of the first drain and the second drain;
• and
• f. means for positioning the cartridge coupled to the cartridge for selectively involving the cartridge relative to the means for dispensing for positioning the vials to receive the selective one or more of the plurality of reagent solutions from the means for dispensing and for moving the cartridge relative to the means for collecting for positioning the selective one of the first drain and the second drain in order to be engaged by the means for collecting.

A synthesizer for forming a polymer chain by sequentially adding monomer units found in a plurality of reagent solutions, the synthesizer comprising:

• a. a first vial for holding a selective one or more of the plurality of reagent solutions during synthesis;
• b. a second vial for holding a selective one or more of the plurality of reagent solutions during synthesis;
• c. a cartridge to hold the first vial and the second vial;
• d. a dispensing system to dispense the selective one or more of the plurality of reagent solutions into the first and second vials;
• e. a drain plate coupled to the cartridge including a first collection area having a first drain configured to collect material from the first vial and a second collection area having a second drain configured to collect material from the second vial;
• f. a purging system to remove material from a selective one of the first vial and the second vial, wherein the purging system is configured to selectively engage one of the first drain and the second drain corresponding to the selective one of the first vial and the second vial and purge material from the selective one of the first vial and the second vial when the purging system engages the selective one of the first drain and the second drain;
• and
• g. a positioning system coupled to the cartridge and configured to selectively move the cartridge relative to the dispensing system to position the vials to receive the selective one or more of the plurality of reagent solutions from the dispensing system and to move the cartridge relative to the purging system to position the selective one of the first drain and the second drain in order to be engaged by the purging system.

A synthesizer for creating a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:

• a. a plurality of vials each for holding material including a selective one of the plurality of reagent solutions during synthesis;
• b. a cartridge for holding the plurality of vials and dividing the plurality of vials into a first bank of vials including at least one of the plurality of vials and a second bank of vials including at least one of the plurality of vials;
• c. a first drain configured to collect material from the first bank of vials;
• d. a second drain configured to collect material from the second bank of vials;
• e. a dispensing system configured to sequentially dispense selective ones of the plurality of reagent solutions into the plurality of vials;
• f. a purging system configured to purge material from a selective one of the first bank of vials and the second bank of vials, wherein the purging system is configured to engage a selective one of the first drain and the second drain corresponding to the selective one of the first bank of vials and the second bank of vials to purge material from the selective one of the first bank of vials and the second bank of vials when the purging system engages the selective one of the first drain and the second drain;
• and
• g. a positioning system coupled to the cartridge and configured to selectively move the cartridge relative to the dispensing system to position the vials to receive the selective one or more of the plurality of reagent solutions from the dispensing system and to move the cartridge relative to the purging system to position the selective one of the first drain and the second drain in order to be engaged by the purging system.