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US 6,270,700 B1Granted
Encapsulation of water soluble peptides
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques
InventorFrancis X. Ignatious
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Abstract
This invention relates to a process for preparing biodegradable microspheres and or nanospheres using an oil-in-water process for the controlled release of bioactive peptides.
Claims16
A process for preparing polymer microspheres comprising a polymer and a peptide, which comprises the steps of:
- neutralizing a peptide salt with a weak base in an aqueous medium wherein said medium comprises a suspension of hydroxyapatite or a solution of calcium mono-hydrogen phosphate to form a precipitate;
- isolating the precipitate;
- suspending the precipitate in an organic solvent, which comprises a polymer dissolved therein to form a suspension;
- dispersing the suspension in an aqueous solution of a surfactant;
- and
- evaporating the organic solvent to isolate the polymer microspheres.
3 more elements
Dependencies are inferred from the claim text.