Intracellular amyloid-beta peptide binding (ERAB) polypeptide
AssigneeThe Trustees of Columbia University in the City of New York
InventorsDavid M. Stern, Shi Du Yan
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Abstract
The present invention provides an isolated nucleic acid encoding an endoplasmic reticulum associated amyloid-beta peptide binding (ERAB) polypeptide. The ERAB polypeptide may comprise human ERAB polypeptide. The present invention provides a purified ERAB polypeptide, as well as a method for treating a neurodegenerative condition in a subject which comprises administering to the subject an agent in amount effective to inhibit ERAB polypeptide binding to amyloid-beta peptide so as to thereby treat the neurodegenerative condition.
Claims2
A purified human endoplasmic reticulum associated amyloid-beta peptide binding (ERAB) polypeptide, comprising the amino acid sequence shown in FIG. 1D (Seq Id No:2).
Dependencies are inferred from the claim text.