Derivatives of GLP-1 analogs

A GLP-1 derivative of formula I (SEQ ID NO:2):

• 7 8 9 10 11 12 13 14 15 16 17 His-Xaa-Xaa-Gly-Xaa-Phe-Thr-Xaa-Asp-Xaa-Xaa- 18 19 20 21 22 23 24 25 26 27 28 Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Phe- 29 30 31 32 33 34 35 36 37 Ile-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa
• wherein
• Xaa at position 8 is Ala,
• Xaa at position 9 is Glu,
• Xaa at position 11 is Thr,
• Xaa at position 14 is Ser,
• Xaa at position 16 is Val,
• Xaa at position 17 is Ser,
• Xaa at position 18 is Ser,
• Xaa at position 19 is Tyr,
• Xaa at position 20 is Leu,
• Xaa at position 21 is Glu,
• Xaa at position 22 is Gly,
• Xaa at position 23 is Gln,
• Xaa at position 24 is Ala,
• Xaa at position 25 is Ala,
• Xaa at position 26 is Lys,
• Xaa at position 27 is Glu,
• Xaa at position 30 is Ala,
• Xaa at position 31 is Trp,
• Xaa at position 32 is Leu,
• Xaa at position 33 is Val,
• Xaa at position 34 is Arg,
• Xaa at position 35 is Gly,
• Xaa at position 36 is Arg, and
• Xaa at position 37 is Gly,
• wherein
• (a) the ε-amino group of Lys at position 26 is substituted with a lipophilic substituent, optionally via a spacer,
• (b) the lipophilic substituent is (i) CH3(CH2)nCO— wherein n is 6, 8, 10, 12, 14, 16, 18, 20 or 22, (ii) HOOC(CH2)mCO— wherein m is 10, 12, 14, 16, 18, 20 or 22, or (iii) lithochoyl, and
• (c) the spacer is (i) an unbranched alkane α,ω-dicarboxylic acid group having from 1 to 7 methylene groups, (ii) an amino acid residue except Cys, or (iii) γ-aminobutanoyl.