US 6,267,981 B1Granted

Method of producing sustained-release preparation

AssigneeTakeda Chemical Industries, Ltd.

InventorsKayoko Okamoto, Yutaka Yamagata, Yasutaka Igari, Masafumi Misaki

Life of this patent

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Abstract

This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.

Claims21

Dependent claims

A method of producing a sustained-release preparation which comprises, in this order:

dispersing a bioactive polypeptide in an organic solvent containing a metal salt of a biodegradeable polymer, and
removing said organic solvent from the resulting dispersion to form a particulate artifact.

Dependencies are inferred from the claim text.

Facts

Application: 09/571,728Filed 15 May 2000 · continuation
Priority: JP 7-16120427 Jun 1995
Granted: 31 Jul 2001
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 38/27
Hormones: growth hormone [GH], i.e. somatotropin
A61K 9/1647
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers: polyesters, e.g. poly
A61K 9/5031
Organic macromolecular compounds: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene…
A61K 38/28
Hormones: insulins

Family

PCT/JP96/01770Parent of this continuation · filed 26 Jun 1996
Application08/714,044Parent of this continuation
US 6,267,981 B1This patent

From the US filing history. Foreign family members aren’t listed.

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