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AssigneeDisetronic Licensing AG
InventorsRudolf Ehwald, Karl-Ernst Ehwald, Andreas Thomas, Uwe Beyer
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The invention concerns a process for affinity viscosimetry and a viscosimetric affinity sensor on the basis of sensitive liquids with analyte-dependent viscosity which are localized within a perfusable dialysis chamber and contain colloidal constituents which are cross-linked by affinity bonds. The viscosimetric affinity sensor according to this invention is characterized by the spatial or temporal separation of analyte diffusion from the measurement of the flow resistance for such sensitive liquid flowing through a capillary, needle-like body or other liquid conductor, which integrated combination of a dialysis chamber with viscosimeter enables a researcher to make measurements under lab conditions that provide spatial separation of the dialysis process from the rheological analysis, as done under test conditions where the maximum shear rate of sensitive liquid in the viscosity sensor is at least twice that shear rate of sensitive liquid experienced in the dialysis chamber. An important advantage of the invention consists in small volume-displacement and negligible structural change within the matrix or organ of living tissue to be investigated.
A process for measuring analyte concentrations by affinity viscosimetry in a liquid known as sensitive to a shear rate applied to said liquid while circulating through an integrated dialysis chamber during a dialysis process, said dialysis process consisting in pumping of a shear sensitive liquid through a liquid conductor for streaming liquids via a flow resistance means with an integrated dialysis chamber and a measuring device for determining viscosity during a measuring process, whereby a maximum shear rate of the sensitive liquid indicated by said viscosimeter measuring device, which occurs at a measuring process, is at least twice the maximum shear rate of the sensitive liquid occurring in a dialysis chamber during the dialysis process.
A viscosimetric sensor needle used in performing affinity viscometry, comprising a blind ending dialysis chamber comprising:
Dependencies are inferred from the claim text.