Oral transmucosal drug dosage using solid solution
AssigneeAnesta Corporation
InventorsHao Zhang, Jed Croft
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Abstract
The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical. The invention provides a drug formulation comprising a solid pharmaceutical agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral cavity, delivering the pharmaceutical agent by absorption through a patient's oral mucosal tissue. The formulation and method provide for improved oral mucosal delivery of the pharmaceutical agent.
Claims55
An improved oral transmucosal solid dosage form drug delivery formulation comprising:
- a pharmaceutical agent capable of being absorbed into oral mucosal tissue having a dissolution rate in the solvents found in the oral cavity,
- a dissolution agent having a dissolution rate in the solvents found in the oral cavity, said dissolution rate of said dissolution agent being greater than said dissolution rate of said pharmaceutical agent, and said pharmaceutical agent being in solid solution with said dissolution agent.
A method for oral transmucosal delivery of a pharmaceutical agent comprising the steps of:
- providing a drug formulation comprising a solid pharmaceutical agent in solid solution with a dissolution agent,
- administering said drug formulation into a patient's oral cavity, and
- delivering said pharmaceutical agent by absorption through a patient's oral mucosal tissue.
An oral mucosal drug formulation comprising:
- a solid solution micro-environment within the drug formulation,
- a drug and a dissolution agent disposed within the solid solution micro-environment, and
- a pharmaceutical ingredient segregated from the micro-environment.
Dependencies are inferred from the claim text.