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US 6,264,917 B1Granted
Targeted ultrasound contrast agents
AssigneeNycomed Imaging AS
InventorsJo Klaveness, Pål Rongved, Dagfinn Løvhaug
Life of this patent
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Abstract
Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.
Claims17
A combined formulation comprising:
- i) a first administrable composition comprising a targetable ultrasound diagnostic agent comprising a suspension in an aqueous carrier liquid of a reporter comprising gas filled microbubbles stabilised by monolayers of film forming surfactant, said microbubbles further comprising at least one vector which binds a target;
- and
- ii) a second administrable composition comprising a substance which displaces or releases said microbubbles from its target.
Dependencies are inferred from the claim text.