In-situ radioactive medical device

A medical device adapted for placement at an intravascular treatment site to inhibit restenosis, the device comprising:

• a device surface;
• a first substance immobilized on said device surface;
• and
• a radioactive second substance suitable for intravascular injection, wherein said first substance is adapted to bind said radioactive second substance when said second substance is intravascularly injected, said second substance being selectively and strongly bound to said first substance.

A kit for inhibiting restenois in blood vessels comprising:

• a stent including
• a tubular body, and
• a first substance immobilized on said tubular body;
• and
• a second substance adapted to bind to said first substance when said second substance is intravascularly injected, said second substance being radioactive, said substance being suitable for injection into the human blood stream.

A system for inhibiting restenosis in blood vessels comprising:

• a radioactive substance suitable for injection into the human blood stream;
• and
• a stent including
• a tubular body, and
• means for binding said radioactive substance when said radioactive substance is intravascularly injected, said binding means being immobilized on said tubular body.

A method for inhibiting restenosis in a stenosed blood vessel region of a patient comprising the steps:

• providing a radioactive substance suitable for injection into the human blood stream;
• providing a medical device having a surface and means for binding said radioactive substance, said binding means connected to said surface;
• placing said device across said stenosed region;
• injecting said radioactive substance into the blood stream, such that said radioactive substance is bound to said binding means.

A method for inhibiting restenosis in a stenosed blood vessel region of a patient comprising the steps:

• providing a medical device having a surface and a first substance immobilized on said surface;
• providing a second substance suitable for injection into the human blood stream, said second substance being radioactive;
• placing said medical device at said stenosed region;
• injecting said second substance into the blood stream, such that said second substance is substantially bound to said first substance.

A medical device adapted for intravascular placement comprising:

• a device surface;
• a first substance immobilized on said surface;
• and
• a second substance suitable for intravascular injection, wherein said first substance is adapted to bind said second substance strongly and selectively when said second substance is intravascularly injected, and wherein said second substance is selected from the group consisting of cytotoxic substances, growth factors, thrombolytic agents and anti-thrombogenic agents.

A method for inhibiting restenosis in a stenosed blood vessel region of a patient comprising the steps:

• providing a medical device having a surface and a first substance immobilized on said surface;
• providing a second substance suitable for injection into the human blood stream, wherein said second substance is selected from the group consisting of cytotoxic substances, growth factors, thrombolytic agents and anti-thrombogenic agents;
• placing said medical device at said stenosed region;
• and
• injecting said second substance into said blood stream, such that said second substance is bound to said first substance.