Retro-, inverso- and retro-inverso synthetic peptide analogues
AssigneeDeakin Research Limited
InventorsAlfio Comis, Margaret Isabel Tyler, Peter Fischer
Life of this patent
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Abstract
Synthetic peptide antigen analogues of native peptide antigens with partial or complete retro, inverso or retro-inverso modifications are provided. When administered as an immunogen to an immunocompetent host the synthetic peptide antigen analogues induce the production of antibodies which recognize the native peptide antigen. Uses of these analogues, vaccines and methods of preparing vaccines comprising these antigen analogues, and antibodies generated using these antigen analogues are also provided.
Claims16
A synthetic peptide antigen analogue of a native peptide antigen, wherein said synthetic peptide antigen analogue is retro-inverso modified to contain all D-amino acids with reversed direction of peptide bonds and reversed termini, with respect to the native antigen, and wherein said synthetic peptide antigen analogue is at least five amino acids in length and induces the production of antibodies which recognize the native peptide antigen.
Dependencies are inferred from the claim text.