Poly(hydroxy acid)/polymer conjugates for skin applications
AssigneeFocal, Inc.
InventorsArthur J. Coury, Luis Z. Avila, Chandrashekhar P. Pathak, Shikha P. Barman
Life of this patent
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Abstract
A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
Claims10
A method for treatment of the skin, comprising topically applying an effective amount of a liquid or semi-solid formulation comprising one or more hydroxy acid copolymers in combination with a suitable carrier for topical application to skin in need of treatment, wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to at least one polymer block, and wherein the hydroxy acid copolymer has the formula
- PaHb,
- wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer, and
- wherein the copolymer further comprises groups capable of being polymerized to crosslink the block copolymers, and
- wherein the formulation is in a form selected from the group consisting of powders, gels, creams, ointments, emulsions, foams, aerosols, sprays, and lotions.
A method for making a liquid or semi-solid cosmetic formulation, comprising mixing one or more hydroxy acid copolymers in combination with a suitable carrier for topical application to skin in need of treatment, wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to at least one polymer block, and wherein the hydroxy acid copolymer has the formula
- PaHb,
- wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer and
- wherein the copolymer further comprises groups capable of being polymerized to crosslink the block copolymers, and
- wherein the formulation is in a form selected from the group consisting of powders, gels, creams, ointments, emulsions, foams, aerosols, sprays, and lotions.
Dependencies are inferred from the claim text.