Diagnostic methods for targeting the vasculature of solid tumors
AssigneeUniversity of Texas System Board of Regents
InventorsPhilip E. Thorpe, Francis J. Burrows
Life of this patent
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Abstract
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
Claims27
A method for imaging a vascularized tumor, comprising administering to an animal having a vascularized tumor a biologically effective amount of a conjugate comprising a selected diagnostic agent linked to a targeting agent that binds to a marker expressed on intratumoral blood vessels, accessible to binding on intratumoral blood vessels or localized on the cell surfaces of intratumoral blood vessels of the vascularized tumor.
Dependencies are inferred from the claim text.