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US 6,261,493 B1Granted
Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods
AssigneeTherics, Inc.
InventorsChristopher M. Gaylo, Walter Flamenbaum, Miles J. Flamenbaum
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Abstract
A method and system for molding a tissue or substitute tissue product in a mold having an exterior surface, and an interior surface, wherein at least one portion of the interior surface is porous and whose pores are in continuous communication with the exterior surface, and wherein said mold can be fabricated using solid free-form fabrication techniques is disclosed.
Claims5
A method for manufacturing a molded product for use as a tissue substitute, comprising:
- a) fabricating a mold having an interior surface and an exterior surface, wherein said mold has at least one portion of said interior surface which is porous and whose pores are in continuous communication with the exterior surface, and wherein said mold comprises an additive, said additive selected from the group consisting of pharmaceuticals, hormones, growth factors, peptides, amino acids, vitamins, enzymes, cellular attractants, living cells, natural tissue extract, fragments of natural tissue, and surface active agents;
- b) filling said mold with a mixture comprising a solid component selected from the group consisting of bioerodible, non-bioerodible and composite materials, and further comprising a liquid substance, at least a portion of which can pass through said pores;
- c) drawing a portion of said liquid substance from said solid component through the pores of said mold to form a solid molded product for use as a tissue substitute;
- and
- d) removing said solid molded product for use as a tissue substitute from said mold.
2 more elements
Dependencies are inferred from the claim text.