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AssigneeElectrofect AS
InventorsIacob Mathiesen, Stig Tollefsen
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A method is disclosed for enhanced vaccination and genetic vaccination of mammals. The vaccination is accomplished by delivering molecules such as proteins and nucleic acids into skeletal muscle and other cells residing in the skeletal muscle in vivo. The protein or nucleic acid is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed.
A method of delivering a DNA molecule to the immune system of a mammal in vivo comprising:
A method of immunizing a mammal with an antigen comprising:
A method of inducing a cellular immune response in a mammal comprising:
A method of inducing a humoral immune response in a mammal comprising:
A method of genetically immunizing a mammal comprising:
A method of delivering a molecule to cells residing within the skeletal muscle of a mammal in vivo comprising:
A method of enhancing an immune response of a mammal comprising:
Dependencies are inferred from the claim text.