Back to results
US 6,258,600 B1Granted
Antisense modulation of caspase 8 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsHong Zhang, Lex M. Cowsert
Life of this patent
Estimating the term…
Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of caspase 8. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding caspase 8. Methods of using these compounds for modulation of caspase 8 expression and for treatment of diseases associated with expression of caspase 8 are provided.
Claims13
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 20, 26, 29, 30, 33, 35, 39, 40, 49, 50, 52, 54, 58, 59, 60, 61, 62, 63, 64, 65, 68, 71, 73, 74, 75, 77, 78, 82, 84, 87, 89, 97, 98, 100, 101, 102, 103, 104, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174 or 175 which inhibits the expression of human caspase 8.
Dependencies are inferred from the claim text.