Functionalization of substrate surfaces with silane mixtures

A substrate having a functionalized surface, comprising:

• a solid support having a plurality of surface hydrophilic, nucleophilic groups, a first fraction of which are covalently bound to an —Si—R1 moiety and a second fraction of which are covalently bound to an —Si(RxRy)—L—R2 moiety, wherein Rx and Ry are independently selected from the group consisting of halogen, lower alkoxy and lower alkyl, R1 is C10 to C18 alkyl, L is C1-C24 alkylene, and R2 is —CH═CH2.

A process for functionalizing the surface of a substrate, comprising:

• contacting a substrate having reactive hydrophilc moieties on the surface there with a derivatizing composition comprising a first silane R1—Si(RLRxRy) and a second silane R2—(L)n—Si(RLRxRy) under reaction conditions effective to couple the silanes to the substrate surface and provide —Si—R1 groups and —Si—(L)n—R2 groups thereon, wherein the RL, moieties, which may be the same or different, are leaving groups, the Rx and Ry are independently lower alkyl or leaving groups, R1 is a chemically inert moiety that upon binding to the substrate surface lowers the surface energy thereof and is selected from the group consisting of C10 to C18 alkyl and benzyl optionally substituted with 1 to 5 halogen atoms, n is 0 or 1, L is a linking group, and R2 is a functional group enabling covalent binding of a molecular moiety or a modifiable group that may be converted to such a functional group.

the process of claim 9, wherein L is a C1-C24 hydrocarbylene linking group substituted with 0 to 6 substituents selected from the group consisting of lower alkyl, hydroxyl, halogen and amino, optionally containing 1 to 6—O—, —S—, —NR—, —CONH—, —(CO)— or —COO— linkages wherein R is hydrogen or lower alkyl.

A process for functionalizing the surface of a substrate, comprising:

• contacting a substrate having reactive hydrophilic moieties on the surface thereof with a derivatizing composition comprising a first silane R1—Si(RLRxRy) and a second silane R2—L—Si(RLRxRy) under reaction conditions effective to couple the silanes to the substrate surface and provide —Si—L—R1 groups and —Si—L—R2 groups thereon, wherein the RL moieties are independently selected from the group consisting of halogen and lower alkoxy, Rx and Ry are independently selected from the group consisting of halogen, lower alkoxy and lower alkyl, R1 is C10 to C18 alkyl, L is C1-C24 alkylene, and R2 is —CH═CH2.

A process for functionalizing the surface of a substrate, comprising:

• contacting a substrate having reactive hydrophilic moieties on the surface thereof with a derivatizing composition comprising a first silane R1—Si(RLRxRy) and a second silane R2—(L)n—Si(RLRxRy) under reaction conditions effective to couple the silanes to the substrate surface and provide —Si—R1 groups and —Si—(L)n—R2 groups thereon, wherein the RL, moieties, which may be the same or different, are leaving groups, the Rx and Ry are independently lower alkyl or leaving groups, R1 is a C10 to C18 chemically inert moiety that upon binding to the substrate surface lowers the surface energy thereof, n is 0 or 1, L is a linking group, and R2 is a functional group enabling covalent binding of a molecular moiety or a modifiable group that may be converted to such a functional group.

A derivatizing composition for functionalizing the surface of a substrate, comprising:

• a first silane R1—Si(RLRxRy) and a second silane R2—(L)n—Si(RLRxRy), wherein the RL are independently leaving groups, the Rx and Ry may be the same or different and are either lower alkyl or leaving groups, R1 is a chemically inert moiety that upon binding to a substrate surface lowers the surface energy thereof and is selected from the group consisting of C10 to C18, alkyl and benzyl optionally substituted with 1 to 5 halogen atoms, n is 0 or 1, L is a linking group, and R2 is a functional group enabling covalent binding of a molecular moiety or a modifiable group that can be converted to such a functional group.

A derivatizing composition for functionalizing the surface of a substrate, comprising a first silane R1—Si(RLRxRy) and a second silane R2—L—Si(RLRxRy), wherein the RL moieties are independently selected from the group consisting of halogen and lower alkoxy, Rx and Ry are independently selected from the group consisting of halogen, lower alkoxy and lower alkyl, R1 is C10 to C18 alkyl, L is C1-C24 alkylene, and R2 is —CH═CH2.