Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
AssigneeShearwater Corporation
InventorJ. Milton Harris
Life of this patent
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Abstract
A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application.
Claims18
A degradable crosslinked polymeric structure comprising hydrolytically unstable linkages between one or more chemically crosslinked nonpeptidic polymers and conjugates of said nonpeptidic polymers and one or more bioactive agents;
- wherein said nonpeptidic polymers are selected from the group consisting of poly(alkylene oxides), poly(oxyethylated polyols), poly(olefinic alcohols), poly(acrylomorpholine), and mixtures thereof;
- and wherein said hydrolytically unstable linkages degrade in aqueous solution to release conjugates of said bioactive agents and said nonpeptidic polymers.
A degradable, chemically crosslinked polymeric structure comprising conjugates of a biologically active molecule and poly(ethylene glycol) (“PEG”) having at least one hydrolytically unstable linkage in the PEG polymer backbone, wherein said hydrolytically unstable PEG is covalently bound to a branched PEG amine.
A chemically crosslinked polymeric structure containing segments of the formula:
- —PEG—T—PEG—W—PEG—W—PEG—T—D
- wherein PEG is a branched or linear poly(ethylene glycol) of molecular weight from about 300 to 200,000 Daltons;
- W is a hydrolytically unstable linkage selected from the group consisting of carboxylate ester, phosphate ester, orthoester, anhydride, imine, acetal, ketal, oligonucleotide, and peptide;
- T is a hydrolytically stable linkage selected from the group consisting of amide, urethane, amino, ether, thioether, and urea;
- and D is a biologically active molecule;
- and wherein said polymeric structure is degradable in aqueous solution and releases into solution conjugates of the biologically active molecule D and PEG.
Dependencies are inferred from the claim text.